| Autor: |
L Iu, Milovanova, L V, Kozlovskaia, Iu S, Milovanov, I N, Bobkova, I A, Dobrosmyslov |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Terapevticheskii arkhiv. 82(6) |
| ISSN: |
0040-3660 |
| Popis: |
The paper deals with the analysis of studies of the role of the bone morphogenetic proteins fibroblast growth factor 23 (FGF-23) and Klothno in the development of vascular wall calcification in chronic renal disease (CRD). FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations. There is evidence that there is an association between high serum FGF-23 levels and vascular wall calcification irrespective of the content of phosphorus and parathyroid hormone. Most authors regard FGF-23 as a potential uremic toxin in patients with end-stage CRD. There are data that support the renoprotective value of the morphogenetic protein Klotho whose expression in CRD is decreased. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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