| Autor: |
Sri N, Batchu, Karina, Thieme, Farigol H, Zadeh, Tamadher A, Alghamdi, Veera Ganesh, Yerra, Mitchell J, Hadden, Syamantak, Majumder, M Golam, Kabir, Bridgit B, Bowskill, Danyal, Ladha, Anthony O, Gramolini, Kim A, Connelly, Andrew, Advani |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Diabetes. 67(11) |
| ISSN: |
1939-327X |
| Popis: |
Blood glucose-lowering therapies can positively or negatively affect heart function in type 2 diabetes, or they can have neutral effects. Dipeptidyl peptidase 4 (DPP-4) inhibitors lower blood glucose by preventing the proteolytic inactivation of glucagon-like peptide 1 (GLP-1). However, GLP-1 is not the only peptide substrate of DPP-4. Here, we investigated the GLP-1-independent cardiac effects of DPP-4 substrates. Pointing to GLP-1 receptor (GLP-1R)-independent actions, DPP-4 inhibition prevented systolic dysfunction equally in pressure-overloaded wild-type and GLP-1R knockout mice. Likewise, DPP-4 inhibition or the DPP-4 substrates substance P or C-X-C motif chemokine ligand 12 (CXCL12) improved contractile recovery after no-flow ischemia in the hearts of otherwise healthy young adult mice. Either DPP-4 inhibition or CXCL12 increased phosphorylation of the Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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