| Autor: |
Sirima, Soodvilai, Paranee, Meetam, Lawan, Siangjong, Ratchanaporn, Chokchaisiri, Apichart, Suksamrarn, Sunhapas, Soodvilai |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Biologicalpharmaceutical bulletin. 43(11) |
| ISSN: |
1347-5215 |
| Popis: |
Cisplatin is a widely used chemotherapy for solid tumors; however, its benefits are limited by serious nephrotoxicity, particularly in proximal tubular cells. The present study investigated the renoprotective effect and mechanisms of germacrone, a bioactive terpenoid compound found in Curcuma species on cisplatin-induced toxicity of renal cells. Germacrone (50 and 100 µM) attenuated apoptosis of human renal proximal tubular cells, RPTEC/TERT1 following treatment with 50 µM cisplatin and for 48 h. Co-treating RPTEC/TERT1 cells with cisplatin and germacrone significantly reduced cellular platinum content compared with cisplatin treatment alone. The effect of germacrone on organic cation transporter 2 (OCT2) which is a transporter responsible for cisplatin uptake was determined. Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
