Osteosarcoma: improved survival with anticoagulation and amputation

Autor:	H C, Hoover, A S, Ketcham, R C, Millar, H R, Gralnick
Rok vydání:	1978
Předmět:	Adult Male Osteosarcoma Time Factors Adolescent Remission Spontaneous Bone Neoplasms Hemorrhage Middle Aged Neoplastic Cells Circulating Amputation Surgical Prothrombin Time Humans Female Warfarin Neoplasm Metastasis
Zdroj:	Cancer. 41(6)
ISSN:	0008-543X
Popis:	A study of warfarin anticoagulation as an adjunct to amputation of osteosarcomas was undertaken after finding dramatic results in experimental systems. Anticoagulation was started 7 days preoperatively, continued during the operation, and for up to six months postoperatively. Three of 21 (14%) non-anticoagulated control patients are alive at 5-11 years. Five of 9 (56%) of the anticoagulated patients remain alive 5-8 years. The presumed mechanism of increased survival is an inhibition of fibrin deposition around circulating tumor cells, thereby preventing their adherence to capillary endothelium to initiate metastasis formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ed189c2f610c6d76d3aae6d1f8271d0e https://pubmed.ncbi.nlm.nih.gov/274994 Zobrazit plný text záznamu Plný text