Autor: |
H C, Hoover, A S, Ketcham, R C, Millar, H R, Gralnick |
Rok vydání: |
1978 |
Předmět: |
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Zdroj: |
Cancer. 41(6) |
ISSN: |
0008-543X |
Popis: |
A study of warfarin anticoagulation as an adjunct to amputation of osteosarcomas was undertaken after finding dramatic results in experimental systems. Anticoagulation was started 7 days preoperatively, continued during the operation, and for up to six months postoperatively. Three of 21 (14%) non-anticoagulated control patients are alive at 5-11 years. Five of 9 (56%) of the anticoagulated patients remain alive 5-8 years. The presumed mechanism of increased survival is an inhibition of fibrin deposition around circulating tumor cells, thereby preventing their adherence to capillary endothelium to initiate metastasis formation. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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