| Autor: |
E A, Kastelijn, C H M, van Moorsel, H J T, Ruven, N M, Korthagen, J M, Kwakkel-van Erp, E A, van de Graaf, P, Zanen, D A, van Kessel, J C, Grutters |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 30(1) |
| ISSN: |
1124-0490 |
| Popis: |
The development of bronchiolitis obliterans syndrome (BOS) after lung transplantation is characterized by inflammation, remodeling and fibrosis. Both YKL-40 and matrix metalloproteinase (MMP)-9 have shown to be involved in these processes. We measured serial YKL-40 and MMP-9 serum levels in lung transplant recipients and assessed their usefulness as biomarker for BOS. Furthermore, we investigate the relationship between these two potential biomarkers of BOS and MMP-7.Ten patients with BOS (BOS(pos)) and 10 matched patients without BOS (BOS(neg)) were included. Serial serum samples were collected after lung transplantation and prior to BOS. YKL-40, MMP-9 and MMP-7 serum levels were determined by ELISA.The median concentrations of YKL-40 did not differ between BOS(pos) and BOS(neg) patients (p0.05). The median concentration of MMP-9 in BOS(pos) patients was significantly higher than in BOS(neg) patients (p0.0001). For MMP-9 as possible risk factor for BOS, a cut off value of 145 ng/ml has a sensitivity of 90% and a negative predictive value of 83%. Longitudinal analysis of YKL-40 and MMP-9 serum levels from the early post-transplant period onwards did not reveal a significant trend in time in both serum levels preceding BOS. In BOS(neg) patients MMP-9 showed an inverse relationship with MMP-7, that was absent in BOS(pos) patients.From the moment of transplantation onwards, patients who eventually developed BOS had significantly increased MMP-9 serum levels in comparison with patients who did not develop BOS. Therefore, increased MMP-9 serum levels might be useful as risk factor for BOS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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