Metalloproteinases and colorectal cancer. Correlation of gene expression and clinical-pathological parameters 1

Autor:	Morini, Sandra Regina, Denadai, Marcos Vinicius, Waisberg, Jaques, Lopes, Gaspar de Jesus, Matos, Delcio, Saad, Sarhan Sydney
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male Metalloproteases Humans Clinical Investigation Adenocarcinoma Colorectal Neoplasms Prognosis Immunohistochemistry Matrix Metalloproteinases Extracellular Matrix Retrospective Studies
Zdroj:	Acta Cirúrgica Brasileira
ISSN:	1678-2674 0102-8650
Popis:	Purpose: To analyze gene and protein expression of metalloproteinases 1, 2, 9, 11 and 16 and their correlation with clinicopathological variables in colorectal adenocarcinoma. Methods: A retrospective study of 114 patients with colorectal adenocarcinoma treated surgically in the period 2006 to 2008 in Hospital de Câncer de Barretos - Fundação Pio XII. The evaluation of gene expression was performed by RT-PCR, and protein by immunohistochemistry. The analysis of gene expression was classified as overexpressed genes and poorly expressed (fold change of approximately 2, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ecfb20a8c72e1b9065562fd8d7537e1a http://europepmc.org/articles/PMC7433662 Zobrazit plný text záznamu