| Autor: |
Lydia J, Davis, Amanda C, Maldonado, Manead, Khin, Aleksej, Krunic, Joanna E, Burdette, Jimmy, Orjala |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
J Nat Prod |
| ISSN: |
1520-6025 |
| Popis: |
The known solid-tumor-selective cytotoxin aulosirazole (1) was identified from bioactive extracts from the culture medium of the cyanobacterium Nostoc sp. UIC 10771. Here, we demonstrate that 1 induces the nuclear accumulation of FOXO3a in OVCAR3 using both Western blot analysis and immunofluorescence confocal microscopy. We also report the discovery of two additional analogues, aulosirazoles B (2) and C (3). Structures for compounds 2 and 3 were determined using HR-ESI-LC-MS/MS and 1D and 2D NMR experiments. Aulosirazoles B (2) and C (3) represent the first natural analogues of the FOXO-activating compound aulosirazole (1) and are the second and third isothiazole-containing metabolites reported from this phylum. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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