Ultrastructural alterations in mouse spermatogenic cells after treatment with anticancer drug biocarbazine

Autor:	Y S, Martinova, D B, Nikolova
Rok vydání:	1990
Předmět:	Dacarbazine Male Mice Mice Inbred BALB C Microscopy Electron Spermatocytes Animals Spermatogenesis Spermatids Spermatogonia
Zdroj:	Zeitschrift fur mikroskopisch-anatomische Forschung. 104(6)
ISSN:	0044-3107
Popis:	Single doses of anticancer drug biocarbazine (BC)--DTIC synonym--were injected intraperitoneally at 50 and 200 mg/kg body weight to sexually mature BALB/c mice. Among other features previously reported (Martinova et al. 1989) BC causes ultrastructural alterations in spermatogonia and spermatocytes significantly expressed after administration of higher dose. In addition BC induces some defects in acrosome formation of early spermatids in Golgi and cap phase, while spermatids in later stages of maturation showed marked resistance to BC treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ecc93e2bb588182edc54a6e1c435c1d2 https://pubmed.ncbi.nlm.nih.gov/2096537 Zobrazit plný text záznamu