| Autor: |
M, Gomez, V, Tybulewicz, D A, Cantrell |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Nature immunology. 1(4) |
| ISSN: |
1529-2908 |
| Popis: |
The GTPase Rac-I has the potential for pleiotropic functions due to its ability to interact with multiple effectors. Here, activation of Rac-I is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) beta selection. An activated Rac-I effector domain mutant that restricts signaling to particular actions on actin dynamics can drive pre-T cell differentiation. Rac-I activation cannot fully substitute for the pre-TCR complex but can fully correct defects in pre-T cell development in mice lacking the adapter molecule Vav-1. The present study identifies the subset of Rac-I responses that mediate Vav-1 action as critical regulators of TCR beta selection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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