| Autor: |
E F, Domino, E K, Zsigmond, V, Kovacs, G, Fekete, P, Stetson |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology and therapeutics. 35(11) |
| ISSN: |
0946-1965 |
| Popis: |
The jet injector route for ketamine was used on 30 children 1-6 years of age undergoing various surgical procedures. A randomly selected dose of 2.5, 3.5, or 6.0 mg/kg of ketamine was given to induce anesthesia. Peak plasma ketamine levels did not follow a simple arithmetic increment related to dose. Dosage based on mg/m2 body surface area or mg/kg body weight provided similar blood levels of ketamine. The beta-phase t1/2 of ketamine in these children was shorter than that found in adults. Considerable individual variability was observed in both the plasma levels to a given dose of jet-injected ketamine and in the beta-phase t1/2. The ketamine beta-t1/2s were not dose related. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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