Expression, purification and virucidal activity of two recombinant isoforms of phospholipase A

Autor:	Raquel Rinaldi, Russo, Nilton Nascimento, Dos Santos Júnior, Adélia Cristina Oliveira, Cintra, Luiz Tadeu Moraes, Figueiredo, Suely Vilela, Sampaio, Victor Hugo, Aquino
Rok vydání:	2018
Předmět:	Protein Folding Crotalus Gene Expression Reptilian Proteins Zika Virus Dengue Virus Antiviral Agents Chromatography Affinity Isoenzymes Phospholipases A2 Escherichia coli Animals Yellow fever virus Snake Venoms
Zdroj:	Archives of virology. 164(4)
ISSN:	1432-8798
Popis:	The global emergence and re-emergence of arthropod-borne viruses (arboviruses) over the past four decades have become a public health crisis of international concern, especially in tropical and subtropical countries. A limited number of vaccines against arboviruses are available for use in humans; therefore, there is an urgent need to develop antiviral compounds. Snake venoms are rich sources of bioactive compounds with potential for antiviral prospection. The major component of Crotalus durissus terrificus venom is a heterodimeric complex called crotoxin, which is constituted by an inactive peptide (crotapotin) and a phospholipase A
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ec8f3b3a1790d54b8880c0de12e06e9c https://pubmed.ncbi.nlm.nih.gov/30809709 Zobrazit plný text záznamu Full text from SpringerLink