| Autor: |
Gisele Capanema, de Oliveira, Sayonarah Carvalho, Rocha, Miliane Alves, da Silva Lopes, Natasha, Paixão, Silmara Lúcia Grego, Alves, Marco Túlio Corrêa, Pessoa, François, Noël, Luis Eduardo M, Quintas, Leandro Augusto, Barbosa, José Augusto Ferreira Perez, Villar, Vanessa Faria, Cortes |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
The Journal of membrane biology. 254(5-6) |
| ISSN: |
1432-1424 |
| Popis: |
Na,K-ATPase (NKA) and cardiotonic steroids (CTS) have shown potent cytotoxic and anticancer effects. Here, we have synthesized a series of CTS digoxin derivatives (γ-benzylidene) with substitutions in the lactone ring and evaluated the cytotoxicity caused by digoxin derivatives in tumor and non-tumor cells lines, as well as their effects on NKA. The cytotoxicity assay was determined in HeLa, A549, and WI-26 VA4 after they were treated for 48 h with increased concentrations of CTS. The effects of CTS on NKA activity and immunoblotting of α1 and β1 isoforms were evaluated at IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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