A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse
| Autor: | M Y, Avila, R A, Stone, M M, Civan |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Dihydropyridines Adenosine Time Factors genetic structures Dose-Response Relationship Drug Receptor Adenosine A2A Receptor Adenosine A3 Receptors Purinergic P1 eye diseases Mice Purinergic P1 Receptor Antagonists Special Reports Purinergic P1 Receptor Agonists Animals Female sense organs Intraocular Pressure |
| Zdroj: | British journal of pharmacology. 134(2) |
| ISSN: | 0007-1188 |
| Popis: | Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo-null electrophysiologic approach recently applied to the mouse, we have identified a diversity of adenosine-receptor mechanisms in modulating IOP in this species. We report the first evidence that A(3) receptors increase IOP in any species, and verify in the mouse reports with larger mammals that A(1) receptors lower and A(2A) receptors increase IOP. |
| Databáze: | OpenAIRE |
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