A high cytosol value of urokinase-type plasminogen activator (uPA) may be predictive of early relapse in primary breast cancer

Autor:	Claudio, Dazzi, Anna, Cariello, Patrizia, Maioli, Serena, Magi, Giovanni, Rosti, Petros, Giovanis, Gloria, Giovannini, Giuseppe, Lanzanova, Maurizio, Marangolo
Rok vydání:	2003
Předmět:	Adult Vascular Endothelial Growth Factor A Time Factors Antigens CD34 Breast Neoplasms Endothelial Growth Factors Cytosol Antigens CD Predictive Value of Tests Recurrence Plasminogen Activator Inhibitor 1 Humans Aged Neoplasm Staging Aged 80 and over Lymphokines Vascular Endothelial Growth Factors Middle Aged Prognosis Urokinase-Type Plasminogen Activator Receptors Estrogen Chemotherapy Adjuvant Lymphatic Metastasis Intercellular Signaling Peptides and Proteins Regression Analysis Female Receptors Progesterone Follow-Up Studies
Zdroj:	Cancer investigation. 21(2)
ISSN:	0735-7907
Popis:	There is now much data that suggest a relationship between angiogenesis and breast cancer prognosis. Angiogenesis is a multistep process resulting from an ordered set of events and regulated by positive and negative modulators of microvessels growth and by the expression of various proteolytic enzymes.We prospectively evaluated VEGF and microvessels density on tumor specimen and cytosolic levels of uPA and PAI-1.We enrolled 81 primary breast cancer patients. The median follow-up was 38 months. Using the median value as cutoff for the statistical analysis, we found significant correlation between cytosolic levels of uPA and PAI-1 (r = 0.61; p.0001), between VEGF and steroid hormone receptor status (p = .01), between PAI-1 and tumor grading (p = .009), and between uPA and tumor size greater than 1 cm (p = .04). With respect to the prognosis, we observed a significant correlation between low uPA levels and RFS and an unforeseen, direct correlation between high VEGF values and better RFS.Our preliminary results indicate that the cytosolic level of uPA at diagnosis may be predictive of early relapse in primary breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ec7d6729e8bd9eaaed947a5d93a313be https://pubmed.ncbi.nlm.nih.gov/12743986 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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