| Autor: |
Jie, Lei, Shi-Qiang, Li, Ya-Fei, Luo, Dian-Yong, Tang, Cheng-He, Zhou, Hong-Yu, Li, Zhi-Gang, Xu, Zhong-Zhu, Chen |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The Journal of organic chemistry. 87(17) |
| ISSN: |
1520-6904 |
| Popis: |
An efficient one-pot reaction of propargylamides, isocyanides, and water catalyzed by zinc was developed for the rapid construction of 2-oxazolines with a wide functional group tolerance. The methylene-3-oxazoline was proven to play a vitally important role to start the tandem cascade transformation through unfunctionalized alkynes with sequential nucleophilic addition approaches of isocyanide and water. Notably, with a slight alteration of the reaction temperature and the addition of one molecule of water, various β-amino amide derivatives were synthesized in good to excellent yields. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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