| Popis: |
Although the advantages of a liquid formulation over a lyophilized one have been mentioned, few studies have quantified the differences between the two. For the purpose of clarifying the advantages of a liquid formulation, we carried out a comparison of ELPLAT I. V. INFUSION SOLUTION, which is a liquid formulation of oxaliplatin, and ELPLAT FOR INJECTION, which is a lyophilized formulation of oxaliplatin. Since multiple factors(such as skill in drug preparation and the dosage)as well as the formulation influenced the preparation time, each factor was assessed by a Latin square design. The mean preparation time was 62. 39 seconds for the liquid formulation and 171. 22 seconds for the lyophilized formulation, and a decrease of approximately two minutes(p0. 0001)was observed with the liquid formulation. Furthermore, after linear regression analysis of multiple factors, shortening of the preparation time was found to be related to the liquid formulation. The preparation time was significantly shortened according to the level of skill in drug preparation with the liquid formulation, but not the lyophilized formulation. This was because the total preparation time was relatively long for the lyophilized formulation. Superior usability of liquid formulation was shown by our quantification of the advantages of liquid oxaliplatin. |
