| Autor: |
La Fontaine, M. D., McDaniel, L. S., Kubicek, L. N., Chappell, R. J., Forrest, L. J., Jeraj, R. |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
Kinetic parameter variability may be sensitive to kinetic model choice, kinetic model implementation or patient-specific effects. The purpose of this study was to assess their impact on the variability of dynamic contrast-enhanced computed tomography (DCE-CT) kinetic parameters. A total of 11 canine patients with sinonasal tumours received high signal-to-noise ratio, test-double retest DCE-CT scans. The variability for three distributed parameter (DP)-based models was assessed by analysis of variance. Mixed-effects modelling evaluated patient-specific effects. Inter-model variability (CV(inter)) was comparable to or lower than intra-model variability (CV(intra)) for blood flow (CV(inter):[4–28%], CV(intra):[28–31%]), fractional vascular volume (CV(inter):[3–17%], CV(intra):[16–19%]) and permeability-surface area product (CV(inter):[5–12%], CV(intra):[14–15%]). The kinetic models were significantly (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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