| Autor: |
Unedo Hence Markus, Sihombing, Andrijono, Gatot, Purwoto, Supriadi, Gandamihardja, Alida R, Harahap, Primariadewi, Rustamadji, Aria, Kekalih, Retno, Widyawati, Dzicky Rifqi, Fuady |
| Rok vydání: |
2022 |
| Zdroj: |
Gynecologic oncology reports. 42 |
| ISSN: |
2352-5789 |
| Popis: |
Ovarian cancer is the 8th deadliest common cancer in women around the world. Almost all ovarian cancer patients would experience chemoresistance, recurrence, and poor prognosis after cytoreductive surgery and platinum-based chemotherapy. Chemoresistant cancer cells have characteristic expressions of cancer stem cell proteins (CSCs) CD44This study was conducted with a prospective cohort of 64 patients who is divided into two groups (32 patients in each group) at the Obstetrics-gynecology and pathology department of Cipto Mangunkusumo, Tarakan, Dharmais, and Fatmawati Hospital. All suspected ovarian cancer patients underwent cytoreductive debulking and histopathological examination. Chemotherapy was given for six series followed by six months of observation. After the observation, we determined the therapy's response with the RECIST Criteria (Response Criteria in Solid Tumors) and then classified the results into chemoresistant or chemosensitive groups. Flow cytometry blood tests were then performed to examine the expression of CD44There was a significant relationship between increased levels of CD44These results indicate that CD44 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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