Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading

Autor:	Yu V, Gritsyna, A D, Ulanova, S S, Popova, A G, Bobylev, V K, Zhalimov, T L, Nemirovskaya, B S, Shenkman, I M, Vikhlyantsev
Rok vydání:	2020
Předmět:	Male Calpain Gene Expression Histone Deacetylases Rats Histone Deacetylase Inhibitors Disease Models Animal Muscular Atrophy Hindlimb Suspension Benzamides Proteolysis Animals Connectin Rats Wistar Muscle Skeletal
Zdroj:	Doklady. Biochemistry and biophysicsREFERENCES. 495(1)
ISSN:	1608-3091
Popis:	The effect of HDACs 4 and 5 on the level of atrophy, calpain-1 and titin content, and TTN gene expression in rat soleus after 7-day gravitational unloading (hindlimb suspension model) was studied. The development of atrophic changes induced by gravitational unloading in rat soleus was accompanied by an increase in the calpain-1 content, an increase in titin proteolysis, and a decrease in the mRNA content of the protein. Inhibition of HDACs 4 and 5 did not eliminate the development of unloading-induced atrophy but significantly prevented proteolysis of titin and the decrease in the TTN gene expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ec2e5263732196400cdb06815fa014a9 https://pubmed.ncbi.nlm.nih.gov/33368047 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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