Characterization of the role of adult neurogenesis in touch-screen discrimination learning
| Autor: | Swan, Alicia A., Clutton, Jonathan Edward, Chary, Priyanka Kesavan, Cook, Sarah G., Liu, Grace G., Drew, Michael R. |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Doublecortin Domain Proteins
Male Neurons Neurogenesis Neuropeptides Mice Transgenic Reversal Learning Antiviral Agents Thymidine Kinase Article Discrimination Learning Mice Inbred C57BL Viral Proteins Space Perception Glial Fibrillary Acidic Protein Visual Perception Animals Simplexvirus Ganciclovir Microtubule-Associated Proteins |
| Popis: | Recent theories posit that adult neurogenesis supports dentate gyrus (DG) pattern separation and is thereby necessary for some types of discrimination learning. Using an inducible transgenic mouse model, we investigated the contribution of adult-born neurons to spatial and nonspatial touch-screen discriminations of varying levels of difficulty. Arresting neurogenesis caused a modest but statistically significant impairment in a position discrimination task. However, the effect was present only on trials after a learned discrimination was reversed, suggesting that neurogenesis supports cognitive flexibility rather than spatial discrimination per se. The deficit was present 4–10 weeks after the arrest of neurogenesis but not immediately after, consistent with previous evidence that the behavioral effects of arresting neurogenesis arise because of the depletion of adult-born neurons at least one month old. The arrest of neurogenesis failed to affect a nonspatial brightness discrimination task that was equal in difficulty to the spatial task. The data suggest that adult neurogenesis is not strictly necessary for spatial or perceptual discrimination learning and instead implicate adult neurogenesis in factors related to reversal learning, such as cognitive flexibility or proactive interference. |
| Databáze: | OpenAIRE |
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