| Autor: |
Maria, Tolia, Andreas, Fotineas, Kalliopi, Nikolaou, Emmanouil, Rizos, Ioanna, Kantzou, Anna, Zygogianni, John, Kouvaris, Kalliopi, Platoni, Panagiotis, Pantelakos, George, Sarris, Nikolaos, Kelekis, Vassilis, Kouloulias |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 19(3) |
| ISSN: |
1107-0625 |
| Popis: |
To prospectively assess the efficacy of the selective serotonin inhibitor escitalopram on painful bone metastases, in combination with external beam irradiation.Forty-three patients with cancer metastatic to bone and suffering from depression were treated with 3 Dimensional Conformal Radiotherapy (3DCRT) (30 Gy; 3 Gy/fraction, 5 days/week) combined with escitalopram (20 mg/day). Pain relief was evaluated with Wong/Baker Faces Pain Scale. The patients reported outcome using a RTOG-EORTC quality-of-life self-questionnaire (QLQ-C30 v3.0) and the status of depression according to Hamilton Scale (HAM-17). The assessment was performed at baseline and 6-8 weeks after radiotherapy.Patients treated with radiotherapy and escitalopram tended to show a good response to pain and improvement of their quality of life.Though our data concerned a rather small number of patients, addition of escitalopram to 3DCRT accomplished a high clinical benefit rate on neuropathic pain from bone metastasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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