| Autor: |
Yu-yan, Zhu, Chui-ze, Kong, Yu, Zeng, Guo-you, Pang, Chun-ming, Yang, Zhi-xi, Sun |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Zhonghua wai ke za zhi [Chinese journal of surgery]. 41(12) |
| ISSN: |
0529-5815 |
| Popis: |
To evaluate the roles of cell adhesion, multidrug resistance and cell proliferation in short-term recurrent cases with superficial bladder cancer, and the prognostic value of the three indexes.Immunohistochemical staining for E-cad, P-gp and Ki-67 was performed on the tumors of 100 patients with stage T0-T1 transitional cell carcinoma of the bladder who had been included in a retrospective research by follow-up.E-cad and P-gp expression was positive in 51 (43.2%)and 17 (14.4%) of the tumors, respectively and mean proliferation index (PI) was 22.1%. The decrease in E-cad expression was accompanied with the increasing recurrent episodes (P0.05), while increase of P-gp expression and PI were accompanied with the increasing recurrence episodes (P0.05). There was significant difference according to E-cad, P-gp positivity and between T(1)G(3) patients and no-T(1)G(3) patients (P0.05). There was negative correlation of E-cad expression with P-gp expression and PI.Minimum adhesion, strong drug resistance and maximum proliferation are the main factors that promote short-term recurrence of superficial bladder cancer and also the inherent reasons for easy recurrence and high malignancy of T(1)G(3) tumors. During this course, the three aspects may interact. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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