Prognostic importance of the soluble form of IL-2 receptorα (sIL-2Rα) and its relationship with surface expression of IL-2Rα (CD25) of lymphoma cells in diffuse large B-cell lymphoma treated with CHOP-like regimen with or without rituximab: a retrospective analysis of 338 cases
| Autor: | Yoko, Hashimoto, Akihiko, Yokohama, Akio, Saitoh, Hirotaka, Nakahashi, Kohtaro, Toyama, Takeki, Mitsui, Hiromi, Koiso, Takayuki, Saitoh, Hiroshi, Handa, Hideki, Uchiumi, Takahiro, Jinbo, Kayoko, Murayama, Morio, Matsumoto, Morio, Sawamura, Masamitsu, Karasawa, Hirokazu, Murakami, Junko, Hirato, Yoshihisa, Nojima, Masaru, Kojima, Norifumi, Tsukamoto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Interleukin-2 Receptor alpha Subunit Middle Aged Prognosis Immunophenotyping Antibodies Monoclonal Murine-Derived Treatment Outcome Doxorubicin Vincristine Antineoplastic Combined Chemotherapy Protocols Humans Prednisone Female Lymphoma Large B-Cell Diffuse Rituximab Cyclophosphamide Aged Neoplasm Staging Retrospective Studies |
| Zdroj: | Journal of clinical and experimental hematopathology : JCEH. 53(3) |
| ISSN: | 1880-9952 |
| Popis: | We evaluated the prognostic significance of the serum level of the soluble form of interleukin-2 receptorα (sIL-2Rα) and investigated its association with CD25 expression on tumor cells in diffuse large B-cell lymphoma (DLBCL). Three hundred and thirty-eight adult patients with newly diagnosed DLBCL were eligible for this retrospective study. 32.2% of patients were treated with CHOP-like regimen and 67.8% with R-CHOP-like regimen. CD25 expression on the surface of tumor cells was evaluated in 143 cases and its relationship with sIL-2Rα level was also investigated. Both overall survival (OS) and progression-free survival (PFS) were poorer in patients with higher sIL-2Rα, in both R-CHOP and CHOP groups. sIL-2Rα1,000 U/mL and performance status (PS) ≥ 2 were independently associated with poorer OS, and sIL-2Rα1,000 U/mL, age60 years, and ≥ 2 extranodal sites were independently associated with poorer PFS in the R-CHOP group. The sIL-2Rα level was higher in the CD25-positive group than in the CD25-negative group in stage 3 or 4 disease (p = 0.010). Multiple linear regression analysis showed CD25 expression to be independently correlated with sIL-2Rα levels. High sIL-2Rα is an important risk factor for survival in DLBCL treated with not only CHOP-like, but also R-CHOP-like regimens, regardless of the tumor's expression of CD25. |
| Databáze: | OpenAIRE |
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