| Autor: |
L E, Semenova, T S, Sherstobitova, I B, Gorokhova |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 39(2-3) |
| ISSN: |
0235-2990 |
| Popis: |
It was shown possible to improve the process of lincomycin production by using batch-type feeding of the carbohydrate substrates during the biosynthesis. The optimal composition of the fermentation medium with lower concentrations of the carbohydrates was developed and batch-type feeding of the substrates was applied. The conditions of the substrate feeding were developed under laboratory conditions. Solutions of glucose or sugar supplemented with potassium sulfate were used for the feeding. The antibiotic yield under the optimal conditions of the substrate feeding and the process control was higher than that under the conditions of the batch fermentation by 23-24 per cent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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