| Autor: |
M, Ahmadi, L, van Hoeven, K, Bokhoven |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nederlands tijdschrift voor geneeskunde. 161 |
| ISSN: |
1876-8784 |
| Popis: |
Toxic epidermal necrolysis (TEN) is a rare disease that is characterised by epidermal loss, often as a result of medication use - particularly sulfonamides and anti-epileptics. People of South-East Asian descent are at increased risk of developing TEN since they may carry the HLA-B*1502 allele.A 61-year-old female of Indonesian descent developed TEN due to carbamazepine use, resulting in admission to the intensive care department of a specialised burn centre in the Netherlands. She was successfully treated with high-dose prednisone and local therapy for the skin disorder.The US Food and Drug Administration advises screening of patients of South-East Asian descent for HLA-B*1502 prior to initiation of treatment with TEN-related medication. In the Netherlands, screening for this allele is currently not mandatory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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