| Autor: |
B F, Crandall, F W, Hanson, S, Keener, M, Matsumoto, W, Miller |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
American journal of obstetrics and gynecology. 168(6 Pt 1) |
| ISSN: |
0002-9378 |
| Popis: |
The purpose of this prospective study was to assess the value of maternal serum screening between 11 and 15 weeks of gestation to detect fetal Down syndrome.Blood samples were collected on 993 women between 11 and 15 weeks' gestation before amniocentesis. Ninety percent wereor = 35 years old. Samples were coded and assayed for alpha-fetoprotein, unconjugated estriol, and human chorionic gonadotropin. Medians were established at each week between 11 and 15 from 836 normal, singleton pregnancies.We used a computer-generated cut-off risk for Down syndrome of one in 365 at term; nine of 11 (82%) Down syndrome pregnancies were identified. There were 23% false-positive results in womenor = 35 years old and 6% in those35 years.These results suggest that maternal serum screening between 11 and 15 weeks may provide an acceptable alternative to screening between 16 and 20 weeks. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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