| Autor: |
L L, Ioannides-Demos, N, Christophidis, P, Ryan, P, Angelis, L, Liolios, A J, McLean |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
The Journal of rheumatology. 24(1) |
| ISSN: |
0315-162X |
| Popis: |
To determine the effect of chronic grapefruit juice administration on steady state blood concentrations of cyclosporine and metabolites in patients with autoimmune diseases.9 patients stabilized on administration of cyclosporine (range 0.7-6.7 mg/kg/day) were given either grapefruit juice or water using randomized crossover design. Whole blood samples were collected before the morning cyclosporine dose and during the 12 h interdose interval. Cyclosporine concentrations were measured using a relatively specific assay (Emit) and total metabolite concentrations were estimated using a nonspecific assay (polyclonal Abbott-TDx).Exposure to grapefruit juice produced significant increases in predose cyclosporine concentrations (p0.01) and total metabolite concentrations (p = 0.03) and the area under the cyclosporine and metabolite blood concentration-time curves (p = 0.005, p = 0.001, respectively). One patient developed significant neurological side effects associated with a 68.9 and 214% increase in predose cyclosporine and metabolite concentrations, respectively, during grapefruit juice co-administration.Grapefruit juice causes an increase in both parent and metabolite profiles, indicating an alteration in the disposition of cyclosporine and metabolites. This interaction is of potential clinical importance in terms of mechanism, side effects, and dosing. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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