| Autor: |
J, Fichna, A, Mokrowiecka, A I, Cygankiewicz, P K, Zakrzewski, E, Małecka-Panas, A, Janecka, W M, Krajewska, M A, Storr |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 24(11) |
| ISSN: |
1365-2982 |
| Popis: |
Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro-inflammatory effects. In this study, we demonstrated for the first time that TRPV4 mRNA expression is up-regulated in patients with inflammatory bowel diseases (IBD). Furthermore, selective blockade of TRPV4 in the 2,4,6-trinitrobenzenesulfonic acid animal model alleviates colitis and pain associated with the intestinal inflammation. Our study indicates that TRPV4 may play a role in mechanisms of defense in intestinal inflammation and that TRPV4 may be an attractive target for future systemic or topic anti-inflammatory treatment in patients with IBD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
