| Autor: |
J E, Kelsey, J S, Aranow, R T, Matthews |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Behavioral neuroscience. 104(5) |
| ISSN: |
0735-7044 |
| Popis: |
Rats previously injected with morphine in a particular environment (paired rats) emitted more withdrawal symptoms in that environment than did rats previously injected with morphine in another environment (unpaired rats) after both 1 day and 5 days of morphine abstinence. Thus, reexposure to an environment previously associated with morphine can elicit context-specific withdrawal even after several days of morphine abstinence. Clonidine (0.06 mg/kg) reduced most of the withdrawal symptoms seen 5 days after morphine abstinence in both the paired and unpaired rats. However, clonidine enhanced many of the withdrawal symptoms in both groups of rats during naltrexone-precipitated withdrawal 1 day after morphine abstinence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
