| Autor: |
C, Sabot, J, Debord, B, Roullet, P, Marquet, L, Merle, G, Lachatre |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology and therapeutics. 33(3) |
| ISSN: |
0946-1965 |
| Popis: |
Moderate and high-dose methotrexate was given by a 4-h infusion to 10 patients. The pharmacokinetics of methotrexate, determined by fluorescence polarization immuno-assay, was successively described by a 2- and a 3-compartment open model with elimination from the central compartment. Population pharmacokinetic parameters were obtained by non-linear regression from 8 data points for each course and were subsequently used to fit the same data by the Bayesian estimation method. According to Akaike's information criterion, the 3-compartment model was found statistically superior in 7 patients out of 10. Using this model clearance was well predicted (+/- 5%) by the Bayesian method with only 2 points taken at the end of the infusion and 24 h after. The prediction was less good for the steady-state volume of distribution (+/- 18%) and the half-lives (+/- 20-30%). This procedure enables a good estimation of individual pharmacokinetic parameters for methotrexate, specially with clearance, at minimal cost and minimal disturbance for the patient. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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