[Effect of subtherapeutic doses of docetaxel (taxotere) on the efficacy of radiotherapy and pro-oxidant-antioxidant balance in rats with Guerin's carcinoma]
| Autor: | V P, Staren'kiĭ, L Ia, Vasil'ev, Iu V, Nikitchenko, N E, Uzlenkova, V N, Dziuba, E P, Medvedeva, Dikiĭ N P |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Glutathione Peroxidase Radiation-Sensitizing Agents Time Factors Radiotherapy Dosage Docetaxel Neoplasms Experimental Antineoplastic Agents Phytogenic Combined Modality Therapy Antioxidants Rats Liver Data Interpretation Statistical Luminescent Measurements Animals Homeostasis Taxoids Lipid Peroxidation Rats Wistar Reactive Oxygen Species Neoplasm Transplantation |
| Zdroj: | Radiatsionnaia biologiia, radioecologiia. 43(6) |
| ISSN: | 0869-8031 |
| Popis: | In the experiments at Wistar male rats the effect of subtherapeutic doses of docetaxel (5 and 10 mg/kg) on the radiotherapy efficacy (20 Gy of single-dose X-rays) namely growth rate of Guerin's tumor and prooxidant-antioxidant balance in liver and blood of animals bearing tumors was investigated. It has been demonstrated that docetaxel at dose 5 mg/kg given 18 hours before irradiation resulted in significant tumor growth delay (2.3-2.7-fold) in comparison with group of rats that received only irradiation. After application of higher dose of docetaxel there was no statistically significant change of tumor size along the whole experiment (14 and 21 days after tumor implantation). Content of lipid peroxidation products was revealed to be considerably increased after chemotherapy and concurrent irradiation when docetaxel was used in a dose of 10 mg/kg. At the same time glutatione peroxidase activity and antioxidative activity of blood plasma were reduced. In the rat liver chemoradiotherapy led to decrease of glutathion peroxidase and glutathione-S-transferase activity to greater degree at docetaxel dose of 10 mg/kg. The obtained results allow to conclude that higher dose of docetaxel and concurrent irradiation resulted in the most effective Guerin's carcinoma growth delay and considerable deviation of antioxidant-prooxidant balance of tissues in the direction of the last. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|