Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: a pre-/post-study

Autor:	K, Manotham, B, Ongvilawan, P, Urusopone, S, Chetsurakarn, J, Tanamai, P, Limkuansuwan, K, Tungsanga, S, Eiam-Ong
Rok vydání:	2012
Předmět:	Adult Male Imidazoles Tetrazoles Middle Aged Kidney Magnetic Resonance Imaging Oxygen Angiotensin Receptor Antagonists Young Adult Humans Diabetic Nephropathies Female Renal Insufficiency Chronic Hypoxia
Zdroj:	Internal medicine journal. 42(4)
ISSN:	1445-5994
Popis:	Chronic intrarenal hypoxia has been regarded as a pathogenic factor of progressive renal damage. However, the lack of available human data has impeded the progress in this field. In this work, blood oxygen level-dependent magnetic resonance imaging was used to determine intrarenal oxygen status pre- and post-angiotensin receptor blockade (olmesartan) treatment in normal subjects, diabetic chronic kidney disease (CKD) patients and non-diabetic CKD patients. The mean R2*, which represents intrarenal oxygenation, was significantly lower in the control group than in the CKD group (12.42 ± 0.53 /s vs 18.89 ± 3.15 /s, P0.01), indicating the presence of intrarenal hypoxia in the CKD patients. The olmesartan treatment induced a 16.2 ± 7.7% decrement of the mean R2* in CKD patients, suggesting that this drug had an intrarenal hypoxia ameliorating effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ea751d538c7553a476dffe90e86c5a13 https://pubmed.ncbi.nlm.nih.gov/22611567 Zobrazit plný text záznamu Plný text