| Autor: |
Jia-Wei, Zhang, Qiang, Zhang, Dong-Bin, Qu, Zhen, Lin, Xue-Ming, Ma, Xin, Zhong, Chao-Hui, Sang, Xu-Shi, Chen, Zu-Kun, Song, Piao, Huang, Jian-Ming, Jiang |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 37(5) |
| ISSN: |
1673-4254 |
| Popis: |
OBJECTIVE: To investigate the association between vitamin D receptor (VDR) gene ApaⅠ polymorphism and the susceptibility to bone and joint tuberculosis in Chinese Han population. METHODS: Between May, 2015 and June, 2016, 100 patients with bone and joint tuberculosis and 100 healthy volunteers were recruited concomitantly in Heyuan Hospital of Traditional Chinese Medicine. Vitamin D receptor gene ApaⅠ polymorphisms in these subjects were analyzed using SNaPshot. RESULT: The genotype frequencies of ApaⅠ-AA, ApaⅠ-Aa and ApaⅠ-aa were 51%, 41%, and 8% in the case group and 33%, 55%, and 12% in the control group, respectively, showing significant differences between the two groups (P < 0.05). The genotype of ApaⅠ-AA was significantly higher in the case group with an odds ratio (OR) of 2.073 (95% CI: 1.142-3.763). CONCLUSION: The ApaⅠ polymorphisms of the VDR gene are associated with the susceptibility to bone and joint tuberculosis in Chinese Han population, and individuals with a ApaⅠ-AA genotype are at greater risks to develop bone and joint tuberculosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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