| Autor: |
F, Mochnacky, V, Bul'kova, R, Holota, J, Zrubakova, L, Slovinska, T, Kiskova, Z, Daxnerova |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 72(6) |
| ISSN: |
1899-1505 |
| Popis: |
For almost three decades, neural stem cells remain still up-to-date and enigmatic topic. The main problem for their studying is the non-existence of an exclusive neural stem cell marker and the heterogeneity of them across the nervous system. As one of the novel markers of neural stem/progenitor cells may serve telomerase reverse transcriptase (TERT), a catalytic subunit of the telomerase enzyme, responsible for retaining the cell immortality. Thus, the aim of our study was to reveal if TERT, as an enzyme for ensuring the immortality of proliferating cells, could be used as a potential marker of neural stem/progenitor cells during the ontogenesis of the rat central nervous system. In this study, we used various markers related to neural stem or progenitor cells character and examined their co-localization with TERT expression. Our experiments were performed on the tissue of the brain and spinal cord during several stages of postnatal development and the neural tube during the 14 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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