[Low prevalence of hepatitis B virus primary drug resistance in Southern Spain]
| Autor: | Marta, Alvarez Estévez, Natalia, Chueca-Porcuna, Vicente, Guillot-Suay, Alejandro, Peña-Monje, Fernando, García-García, Federico, García-García |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Aged 80 and over Male Hepatitis B virus Adolescent Genes Viral Mutation Missense Gene Products pol Middle Aged Antiviral Agents Young Adult Hepatitis B Chronic Lamivudine Spain Child Preschool Drug Resistance Viral Prevalence Humans Point Mutation Reverse Transcriptase Inhibitors Female Hepatitis B Vaccines Prospective Studies Child Aged |
| Zdroj: | Enfermedades infecciosas y microbiologia clinica. 31(8) |
| ISSN: | 1578-1852 |
| Popis: | To know the prevalence of primary resistance in chronic hepatitis B naïve patients is essential to decide on the need of routine laboratory testing.The genetic sequence of the HBV polymerase from 105naïve patients was analysed.rtV173L, a lamivudine compensatory mutation, was detected in two patients (1.9%), rtI233V in one patient, and another one carried the sG145R vaccine escape mutation.Our study shows that studying HBV resistance in naïve patients should not be recommended in the routine laboratory setting, for the time being. |
| Databáze: | OpenAIRE |
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