| Autor: |
Guillermo A, Martínez-Nieto, Hanna-Riikka, Teppo, Noora, Petrelius, Valerio, Izzi, Raman, Devarajan, Tiina, Petäistö, Hengshuo, Liu, Kris S, Kim, Sanna-Maria, Karppinen, Heli, Ruotsalainen, Jarkko, Koivunen, Joni M, Mäki, Gilbert C, Walker, Taina, Pihlajaniemi, Donald, Gullberg, Ritva, Heljasvaara |
| Rok vydání: |
2022 |
| Zdroj: |
Frontiers in oncology. 12 |
| ISSN: |
2234-943X |
| Popis: |
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated fibroblasts (CAFs) in various human neoplasms. We investigated α11 expression in human cutaneous squamous cell carcinoma (cSCC) and in benign and premalignant human skin lesions and monitored its effects on cSCC development by subjecting α11-knockout ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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