| Autor: |
Fei, Gao, Jie Min, Pan, Xu Hong, Hou, Qi Chen, Fang, Hui Juan, Lu, Jun Ling, Tang, Hui Lin, Gu, Zhi Jian, Pan, You Hua, Yao, Wei Zhen, Shen, Wei Ping, Jia |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Biomedical and environmental sciences : BES. 25(1) |
| ISSN: |
0895-3988 |
| Popis: |
To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.A total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement.Liver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI): 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI): 2.66 (1.53-4.65) P=0.00].Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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