| Autor: |
E, Tarasów, A, Wiercińska-Drapało, B, Kubas, W, Dzienis, A, Orzechowska-Bobkiewicz, D, Prokopowicz, J, Walecki |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Acta radiologica (Stockholm, Sweden : 1987). 44(2) |
| ISSN: |
0284-1851 |
| Popis: |
To detect early metabolic changes in the brain of neurologically asymptomatic HIV-infected patients with normal MR imaging and to find the correlation between 1H MR results and immune status.Twenty neurologically asymptomatic HIV seropositive patients underwent MR imaging and single-voxel 1H MR spectroscopy (MRS) using a PRESS sequence. For all patients, the signals from N-acetyl-aspartate (NAA), choline-containing compounds (Cho), creatine-phosphocreatine (Cr) and myoinositol (mI) were compared with 32 healthy volunteers as metabolite ratios and metabolite areas to non-suppressed water area ratios.In HIV patients, the NAA/Cho ratio was significantly lower ( p0.01), but there were no changes in NAA/Cr ratio. A statistically significant reduction in NAA/H2O and Cr/H2O (both p0.05) was observed. For the immune status there was a statistically significant correlation (r=0.47, p0.05) between CD4 counts and NAA/H2O ratio. A significant increase in Cho/Cr ( p0.001) and mI/Cr ( p0.01) ratios in HIV patients was found, but Cho/H2O and mI/H2O concentrations were non-significantly increased.These results indicate that neuronal loss and gliosis in HIV-infected patients may be associated with impairment of energy metabolism. The spectral changes found suggest that 1H MRS can be used for early detection of brain damage induced by HIV. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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