| Autor: |
Nikos, Vasilakis, Anna P, Durbin, Amelia P A Travassos, da Rosa, Jorge L, Munoz-Jordan, Robert B, Tesh, Scott C, Weaver |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
The American journal of tropical medicine and hygiene. 79(1) |
| ISSN: |
1476-1645 |
| Popis: |
Sylvatic dengue viruses (DENVs) are transmitted between non-human primates and arboreal Aedes spp. mosquitoes in Southeast Asia and west Africa. Recent evidence suggests that the risk for re-emergence of sylvatic DENV into the urban endemic/epidemic cycle may be high, which could limit the potential for eradicating the human transmission cycle with vaccines now under development. We assessed the likelihood of sylvatic DENV re-emergence in the face of immunity to current endemic strains or vaccines by evaluating the neutralization capacity of sera from DENV vaccinees and convalescent patients after primary infection with DENV-2 and DENV-3 serotypes. Our data indicate robust homotypic cross-immunity between human sera and sylvatic DENV strains, but limited heterotypic neutralization. Should a licensed vaccine lead to the eradication of the urban transmission cycle in the future, re-emergence of sylvatic strains into the urban cycle would be limited by homotypic immunity mediated by virus-neutralizing antibodies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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