[The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words]
| Autor: | V E, Golimbet, Zh V, Garakh, G I, Korovaitseva, T V, Lezheiko, Yu S, Zaytsevac, I Ya Gurovich, A B, Shmukler, G I, Rodionov, V B, Strelets |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Adolescent Brain-Derived Neurotrophic Factor Gene Expression Middle Aged Russia Schizotypal Personality Disorder Cognition Psychotic Disorders Case-Control Studies Evoked Potentials Auditory Schizophrenia Speech Perception Humans Speech Female Alleles |
| Zdroj: | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. 66(5) |
| ISSN: | 0044-4677 |
| Popis: | We explored the association of brain-derived neurotrophic factor (BDNF) and serotonin transporter genes with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and healthy people. It has been shown that Val66Met and 5-HTTLPR polymorphisms are associated with P100 and N170 during the passive reading of single words written in Russian presented with different occurrence frequency. The healthy carriers of the ValVal genotype (BDN F Val66Met) allele or the SS (5-HTTLPR) genotype performed the task better compared to those with an Met or an L allele. The differences were significant in healthy people and observed as a trend in thepatients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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