| Autor: |
Mohamed, Abbas, Anne, Cori, Samuel, Cordey, Florian, Laubscher, Tomás, Robalo Nunes, Ashleigh, Myall, Julien, Salamun, Philippe, Huber, Dina, Zekry, Virginie, Prendki, Anne, Iten, Laure, Vieux, Valérie, Sauvan, Christophe E, Graf, Stephan, Harbarth |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
eLife. 11 |
| ISSN: |
2050-084X |
| Popis: |
There is ongoing uncertainty regarding transmission chains and the respective roles of healthcare workers (HCWs) and elderly patients in nosocomial outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in geriatric settings.We performed a retrospective cohort study including patients with nosocomial coronavirus disease 2019 (COVID-19) in four outbreak-affected wards, and all SARS-CoV-2 RT-PCR positive HCWs from a Swiss university-affiliated geriatric acute-care hospital that admitted both Covid-19 and non-Covid-19 patients during the first pandemic wave in Spring 2020. We combined epidemiological and genetic sequencing data using a Bayesian modelling framework, and reconstructed transmission dynamics of SARS-CoV-2 involving patients and HCWs, to determine who infected whom. We evaluated general transmission patterns according to case type (HCWs working in dedicated Covid-19 cohorting wards: HCWDuring the study period (1 March to 7 May 2020), we included 180 SARS-CoV-2 positive cases: 127 HCWs (91 HCWMost importation events were linked to HCW. Unexpectedly, transmission between HCWThis study was supported by a grant from the Swiss National Science Foundation under the NRP78 funding scheme (Grant no. 4078P0_198363). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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