| Autor: |
H, Rivera, L M, Ayala-Madrigal, M, Gutiérrez-Angulo, A I, Vasquez, A L, Ramos |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Genetic counseling (Geneva, Switzerland). 14(2) |
| ISSN: |
1015-8146 |
| Popis: |
We report here on two mosaic patients with both an idic(Yp) and a microchromosome. FISH with the DYZ3 alphoid repeat demonstrated that the isodicentrics effectively exhibited two alphoid clusters whereas the small markers had a Y-centromere. These data, along with 4 previous observations, indicate that such microchromosomes effectively result from functional dicentricity of isodicentric Y-chromosomes and represent the excision of one centromere plus various amounts of adjacent chromatin. Other than a real infrequency of such a concurrence or a very low proportion of the cell line(s) containing the microchromosome, the paucity of observations points to a high rate of underdiagnosis as revealed by two idic(Y) instances in which the microchromosome was detected only in samples assessed by FISH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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