[Candesartan inhibits the angiotensin II-induced proliferation and migration of rat thoracic aortic smooth muscle A7r5 cells and its mechanism]

Autor: Ziting, Dang, Aimei, Zhang, Qihua, Jia, Chaoyang, Tan, Xiaojing, Zhang, Li, Li, Ketao, Ma, Junqiang, Si
Rok vydání: 2019
Předmět:
Zdroj: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 35(2)
ISSN: 1007-8738
Popis: Objective To investigate the effect of candesartan on angiotensin II (Ang II)-induced proliferation and migration of vascular smooth muscle cells and its effect on connexin 43 (Cx43). Methods A7r5 cells were cultured in vitro and randomly divided into control group, AngII group and AngII combined with candesartan group. Cell viability was detected by CCK-8 assay; the migration and invasion ability of A7r5 cells were measured by wound-healing and Transwell
Databáze: OpenAIRE