Prediction of blood cyclosporine concentrations in haematological patients with multidrug resistance by means of total, lean and different adipose factors dosing body weight using Bayesian and non-linear least squares methods

Autor:	G, Wu, M, Furlanut
Rok vydání:	1996
Předmět:	Adult Male Body Weight Bayes Theorem Middle Aged Hematologic Diseases Drug Resistance Multiple Sex Factors Bias Cyclosporine Linear Models Humans Female Least-Squares Analysis Immunosuppressive Agents Software
Zdroj:	International journal of clinical pharmacology research. 16(4-5)
ISSN:	0251-1649
Popis:	In the present work, we have studied the prediction of blood cyclosporine (CsA) concentrations in haematological patients with multidrug resistance by means of total body weight, 25, 50 and 75 adipose factor dosing body weight, and lean body weight using the Bayesian method (BM) and non-linear least squares method (NLLSM) during the second course of CsA treatment. The results showed that both BM and NLLSM can minimize the prediction difference among different dosing body weight parameter types. The results also slightly favour the predictions with lean body weight.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e960c3cc84db1039d45573be7e76b151 https://pubmed.ncbi.nlm.nih.gov/9172006 Zobrazit plný text záznamu