| Autor: |
Raniero, Chimienti, Tania, Baccega, Silvia, Torchio, Fabio, Manenti, Silvia, Pellegrini, Alessandro, Cospito, Angelo, Amabile, Marta Tiffany, Lombardo, Paolo, Monti, Valeria, Sordi, Angelo, Lombardo, Mauro, Malnati, Lorenzo, Piemonti |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cell reports. 40(13) |
| ISSN: |
2211-1247 |
| Popis: |
Induced pluripotent stem cells (iPSCs) represent a source from which β cells can be derived for diabetes replacement therapy. However, their application may be hindered by immune-mediated responses. Although abrogation of major histocompatibility complex class I (MHC-I) can address this issue, it may trigger natural killer (NK) cells through missing-self recognition mechanisms. By profiling the relevant NK-activating ligands on iPSCs during in vitro differentiation into pancreatic β cells, we find that they express high levels of B7-H3 and CD155. Hypothesizing that such surface ligands could be involved in the amplification of NK-activating signals following missing-self, we generate MHC-I-deprived B7-H3 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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