Sry-negative XX sex reversal in a family of Norwegian Elkhounds

Autor:	J R, Melniczek, D, Dambach, U, Prociuk, P F, Jezyk, P S, Henthorn, D F, Patterson, U, Giger
Rok vydání:	1999
Předmět:	Male Dogs X Chromosome Disorders of Sex Development Animals Female DNA Dog Diseases Genitalia Male Polymerase Chain Reaction Gene Deletion Sex Chromosome Aberrations Pedigree
Zdroj:	Journal of veterinary internal medicine. 13(6)
ISSN:	0891-6640
Popis:	Two related female Norwegian Elkhounds were evaluated at 6 and 8 months of age for enlarged clitori. Both had a 78 XX karyotype. Histology of their internal reproductive tracts demonstrated 1 to be an XX true hermaphrodite with bilateral ovotestes and the other to be an XX male with bilateral aspermatogenic testes. Polymerase chain reaction-based tests of genomic DNA showed that both dogs lacked Sry, the testis-determining gene. Pedigree analysis was consistent with an autosomal recessive mode of inheritance, as has been reported in the American Cocker Spaniel and the German Shorthaired Pointer. This is the 1st reported case of familial Sry-negative XX sex reversal in the Norwegian Elkhound. A summary of 34 previously unreported cases of dogs with masculinized external genitalia and a normal 78 XX karyotype seen from 1980 to 1997 is given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e8f75dc85d85e834fb67e8559a49a477 https://pubmed.ncbi.nlm.nih.gov/10587257 Zobrazit plný text záznamu Plný text