| Autor: |
Petru Octavian, Drăgoescu, Ştefania, Tudorache, Andrei Ioan, Drocaş, George, Mitroi, Andrei, Pănuş, Nicoleta Alice Marilena, Drăgoescu, Cristian, Meşină, Cosmin Daniel, Mititelu, Andreea Doriana, Stănculescu, Guleed, Mohamed, Paul Ioan, Tomescu |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 58(4) |
| ISSN: |
2066-8279 |
| Popis: |
Bladder cancer (BC) currently accounts for 5% of all malignancies and the most common tumor of the urinary tract. Diagnosis of bladder cancer is based on urine cytology and white-light cystoscopy (WLC) performed for patients with suspected bladder mass and÷or hematuria. Recent studies suggest that using the fluorescence photodynamic diagnosis (PDD) significantly improves diagnostic sensitivity with a positive influence upon the recurrence rate of bladder cancer.To evaluate the diagnostic efficiency and long-term influence upon the tumor recurrence rate for patients with non-muscle-invasive bladder cancer (NMIBC) undergoing hexaminolevulinate PDD compared to standard WLC.Between 2009 and 2011, 113 primary NMIBC patients were enrolled in our prospective study and randomized in two parallel groups: 57 patients in the study group (PDD) and 56 patients in the control group (WLC). All patients had primary Ta÷T1 NMIBC with good life expectancy and no significant bladder outlet obstruction [postvoid residual urine volume (PVR)100 mL].Fluorescence cystoscopy examination identified 26.3% more tumors than the conventional examination (p=0.034) in the PDD group. Tumor recurrence rate analysis proved a significant reduction by up to 20% after five years of follow-up by using PDD [hazard ratio (HR) 0.566, 95% confidence interval (CI) 0.343-0.936; p=0.0267].The use of PDD for patients with NMIBC results in a significant 26% diagnostic sensitivity improvement as well as superior patient prognosis and quality of life following conservative treatment by reducing the tumor recurrence rate with up to 20% after five years of follow-up. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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