Short-term low-dose pantoprazole-based triple therapy for cure of Helicobacter pylori infection in duodenal ulcer patients

Autor:	P, Pazzi, R, Scagliarini, S, Gamberini, V, Matarese, C, Rizzo, S, Gullini
Rok vydání:	1998
Předmět:	Adult Male Helicobacter pylori Antitrichomonal Agents Middle Aged Anti-Ulcer Agents Combined Modality Therapy 2-Pyridinylmethylsulfinylbenzimidazoles Tinidazole Anti-Bacterial Agents Helicobacter Infections Treatment Outcome Clarithromycin Duodenal Ulcer Sulfoxides Humans Benzimidazoles Female Prospective Studies Pantoprazole Omeprazole Aged
Zdroj:	Alimentary pharmacologytherapeutics. 12(8)
ISSN:	0269-2813
Popis:	The eradication of Helicobacter pylori infection has been achieved using various therapy regimens, but the efficacy of the proton-pump inhibitor pantoprazole as part of these regimens has not yet been widely tested.To evaluate the efficacy and tolerability of a 1-week low-dose pantoprazole-based triple therapy in patients with H. pylori-positive duodenal ulcer.In an open single-centre prospective study, 71 patients with endoscopically proven active duodenal ulcer and H. pylori infection received pantoprazole 40 mg o.m. for 4 weeks, and during the first week a combination antimicrobial treatment comprising tinidazole 500 mg b.d. plus clarithromycin 250 mg b.d. H. pylori eradication was defined as concordant negative histology and rapid urease test performed at endoscopy 4-6 weeks after the end of treatment, confirmed 4 weeks later by 13C-urea breath test.Sixty-six patients (93%) completed the trial and five patients were lost to follow-up. H. pylori infection was cured in 61 out of the 66 patients who completed the trial (per-protocol analysis: 92.4%, 95% CI: 83.2-97.5%; intention-to-treat analysis: 85.9%, 95% CI: 75.7-93.0%). At final endoscopy, 65 out of 66 patients had healed ulcer (98.5%). Mild adverse events occurred in six patients (9.1%).One-week low-dose pantoprazole-based triple therapy is a simple, effective and well-tolerated regimen for ulcer healing and H. pylori eradication in patients with duodenal ulcer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e8b2724505dd4d32ee4f0253abdbf554 https://pubmed.ncbi.nlm.nih.gov/9726385 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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