Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands
| Autor: | G M, Pighetti, W, Novosad, C, Nicholson, D C, Hitt, C, Hansens, A B, Hollingsworth, M L, Lerner, D, Brackett, S A, Lightfoot, J M, Gimble |
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| Rok vydání: | 2001 |
| Předmět: |
9
10-Dimethyl-1 2-benzanthracene Anticholesteremic Agents Mammary Neoplasms Experimental Receptors Cytoplasmic and Nuclear Antineoplastic Agents Ligands Rats Thiazoles Troglitazone Cholesterol Pyrimidines Treatment Outcome Carcinogens Disease Progression Animals Female Peroxisome Proliferators Thiazolidinediones Chromans Triglycerides Transcription Factors |
| Zdroj: | Anticancer research. 21(2A) |
| ISSN: | 0250-7005 |
| Popis: | The objective of this study was to evaluate the ability of troglitazone (a thiazolidinedione) and Wy-14,643 (a clofibrate) to inhibit progression of non-detectable and detectable mammary tumors in rats induced by 7,12 dimethylbenz(a)anthracene (DMBA) when compared to those receiving no treatment or tamoxifen. Although not as effective as tamoxifen in decreasing overall tumor incidence, Wy-14,643 reduced the percentage and number of malignant tumors that developed when compared to both troglitazone and control. Treatment of detectable tumors with either Wy-14,643 or troglitazone induced regression or stasis of total tumor volume in 40-50% of the animals, compared to only 10% in control and 65% in tamoxifen treated animals. Moreover, each PPAR ligand was as effective as tamoxifen in preventing additional tumor development. In summary, both PPAR ligands were more effective than no treatment in preventing tumor progression once detected. However, only the PPAR-alpha activator, Wy-14,643 was able to reduce the development of malignant tumors when administered prior to detection. |
| Databáze: | OpenAIRE |
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